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KMID : 0359319960360010065
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Korean Journal of Veterinary Research
1996 Volume.36 No. 1 p.65 ~ p.74
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Effect of superoxide anion in the regulation of artrial natriuretic peptide ( ANP ) secretion
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Abstract
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Atrial Natriuretic Peptide(ANP) is a hormone with potent natriuretic, diuretic and relaxing properties of vascular smooth muscle. Specific chemical modulator responsible for the ANP secretion has not yet been found. Although atrial stretch of stretch-release is to be a major stimulus for the secretion of ANP, the precise mechano-molecular transduction mechanism responsible for its evoked secretion remains to be elucidated. It is interested to clarify the effect of superoxide anion in the stretch-induced ANP secretion. In order to investigate the effectg of H₂O₂ in the regulation of ANP secretion, a perfused model of left atrium of rats was used. The results obtained were as follows;
1. The ANP secretion and the extracellular fluid(ECF) translocation were accentuated by the effect of repetitive atrial distension-reduction volume at atrial pressure(4cmH₂O).
2. The dilution curve showed to be in parallel between pure atriopeptin Ⅲ (AP Ⅲ) and perfusated buffer.
3. H₂O₂(5×10^(-4)M) accenturated a strectch-release induced increase of the ANP secretion. The amount of released ANP was significantly(p<0.01) increased. These results suggest that the superoxide anion may be involved in the regulatory mechanism of mechanically activated ANP release.
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